Tuesday, April 30, 2013

Rare, lethal childhood disease tracked to protein

Rare, lethal childhood disease tracked to protein [ Back to EurekAlert! ] Public release date: 29-Apr-2013
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Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

(CHICAGO) - A team of international researchers led by Northwestern Medicine scientists has identified how a defective protein plays a central role in a rare, lethal childhood disease known as Giant Axonal Neuropathy, or GAN. The finding is reported in the May 2013 Journal of Clinical Investigation.

GAN is an extremely rare and untreatable genetic disorder that strikes the central and peripheral nervous systems of young children. Those affected show no symptoms at birth; typically around age three the first signs of muscle weakness appear and progress slowly but steadily. Children with GAN experience increasing difficulty walking and are often wheelchair-bound by age 10. Over time, they become dependent on feeding and breathing tubes. Only a few will survive into young adulthood.

In GAN patients, nerve cells are swollen with massive build-ups of structures called intermediate filaments, cytoskeletal components that give cells their shape and mechanical properties. Goldman's team found that gigaxonin, a protein encoded by the gene involved in GAN, regulates normal turnover of the protein building blocks that form a cell's intermediate filaments. Mutations in this gene result in the malfunctioning of gigaxonin, which leads to the abnormal build-up of intermediate filaments and eventually disrupts the normal functioning of nerve cells.

"This important new research pinpoints the mechanism that allows intermediate filaments to rapidly build up in GAN patients," says Robert Goldman, chair of the department of cell and molecular biology at Northwestern University Feinberg School of Medicine. Goldman has studied the structural proteins of cells for more than 30 years.

"This is a huge step forward for GAN research," said Lori Sames, co-founder and CEO of Hannah's Hope Fund, the leading GAN disease organization. "GAN is juvenile ALS, but even worse. Not only do motor neurons die out, so do the sensory neurons. To find a medicinal therapy, you really need to know what mechanism to target. And thanks to Dr. Goldman's work, now we do."

To identify gigaxonin's role, scientists used cells known as fibroblasts obtained from skin biopsies of children with GAN. The cells were then grown in lab cultures, and they also contained large abnormal aggregates of intermediate filaments. When scientists introduced healthy gigaxonin genes into both control and patient fibroblasts, the results were dramatic. The abnormal aggregates of intermediate filaments disappeared. However, the cytoskeleton's two other major systems, microtubules and actin filaments were not affected by this treatment.

The study's lead author, Northwestern University postdoctoral fellow Saleemulla Mahammad, stressed that this discovery may also have implications for more common types of neurodegenerative diseases that are also characterized by large accumulations of intermediate filament proteins, including Alzheimer's disease and Parkinson's disease.

"Our results suggest new pathways for disease intervention," he said. "Finding a chemical component that can clear the intermediate filament aggregations and restore the normal distribution of intermediate filaments in cells could one day lead to a therapeutic agent for many neurological disorders."

Mahammad and other members of the Goldman Laboratory collaborated with Puneet Opal, M.D., associate professor in the Ken and Ruth Davee department of neurology and cell and molecular biology, along with researchers in the laboratory of Pascale Bomont, at the INSERM neurological institute in Montpelier, France, and the laboratory of Jean-Pierre Julien at the Universit Laval in Quebec, Canada.

###

This research was supported by the National Institute of General Medical Sciences NIH grant 1P01GM096971-01 and Hannah's Hope Fund. The leading GAN disease foundation, Hannah's Hope Fund, was established in 2008, and currently knows of 38 cases of the disease worldwide. The foundation is currently working towards funding a clinical trial for GAN gene therapy.


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Rare, lethal childhood disease tracked to protein [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

(CHICAGO) - A team of international researchers led by Northwestern Medicine scientists has identified how a defective protein plays a central role in a rare, lethal childhood disease known as Giant Axonal Neuropathy, or GAN. The finding is reported in the May 2013 Journal of Clinical Investigation.

GAN is an extremely rare and untreatable genetic disorder that strikes the central and peripheral nervous systems of young children. Those affected show no symptoms at birth; typically around age three the first signs of muscle weakness appear and progress slowly but steadily. Children with GAN experience increasing difficulty walking and are often wheelchair-bound by age 10. Over time, they become dependent on feeding and breathing tubes. Only a few will survive into young adulthood.

In GAN patients, nerve cells are swollen with massive build-ups of structures called intermediate filaments, cytoskeletal components that give cells their shape and mechanical properties. Goldman's team found that gigaxonin, a protein encoded by the gene involved in GAN, regulates normal turnover of the protein building blocks that form a cell's intermediate filaments. Mutations in this gene result in the malfunctioning of gigaxonin, which leads to the abnormal build-up of intermediate filaments and eventually disrupts the normal functioning of nerve cells.

"This important new research pinpoints the mechanism that allows intermediate filaments to rapidly build up in GAN patients," says Robert Goldman, chair of the department of cell and molecular biology at Northwestern University Feinberg School of Medicine. Goldman has studied the structural proteins of cells for more than 30 years.

"This is a huge step forward for GAN research," said Lori Sames, co-founder and CEO of Hannah's Hope Fund, the leading GAN disease organization. "GAN is juvenile ALS, but even worse. Not only do motor neurons die out, so do the sensory neurons. To find a medicinal therapy, you really need to know what mechanism to target. And thanks to Dr. Goldman's work, now we do."

To identify gigaxonin's role, scientists used cells known as fibroblasts obtained from skin biopsies of children with GAN. The cells were then grown in lab cultures, and they also contained large abnormal aggregates of intermediate filaments. When scientists introduced healthy gigaxonin genes into both control and patient fibroblasts, the results were dramatic. The abnormal aggregates of intermediate filaments disappeared. However, the cytoskeleton's two other major systems, microtubules and actin filaments were not affected by this treatment.

The study's lead author, Northwestern University postdoctoral fellow Saleemulla Mahammad, stressed that this discovery may also have implications for more common types of neurodegenerative diseases that are also characterized by large accumulations of intermediate filament proteins, including Alzheimer's disease and Parkinson's disease.

"Our results suggest new pathways for disease intervention," he said. "Finding a chemical component that can clear the intermediate filament aggregations and restore the normal distribution of intermediate filaments in cells could one day lead to a therapeutic agent for many neurological disorders."

Mahammad and other members of the Goldman Laboratory collaborated with Puneet Opal, M.D., associate professor in the Ken and Ruth Davee department of neurology and cell and molecular biology, along with researchers in the laboratory of Pascale Bomont, at the INSERM neurological institute in Montpelier, France, and the laboratory of Jean-Pierre Julien at the Universit Laval in Quebec, Canada.

###

This research was supported by the National Institute of General Medical Sciences NIH grant 1P01GM096971-01 and Hannah's Hope Fund. The leading GAN disease foundation, Hannah's Hope Fund, was established in 2008, and currently knows of 38 cases of the disease worldwide. The foundation is currently working towards funding a clinical trial for GAN gene therapy.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/nu-rlc042913.php

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In a first, black voter turnout rate passes whites

WASHINGTON (AP) ? America's blacks voted at a higher rate than other minority groups in 2012 and by most measures surpassed the white turnout for the first time, reflecting a deeply polarized presidential election in which blacks strongly supported Barack Obama while many whites stayed home.

Had people voted last November at the same rates they did in 2004, when black turnout was below its current historic levels, Republican Mitt Romney would have won narrowly, according to an analysis conducted for The Associated Press.

Census data and exit polling show that whites and blacks will remain the two largest racial groups of eligible voters for the next decade. Last year's heavy black turnout came despite concerns about the effect of new voter-identification laws on minority voting, outweighed by the desire to re-elect the first black president.

William H. Frey, a demographer at the Brookings Institution, analyzed the 2012 elections for the AP using census data on eligible voters and turnout, along with November's exit polling. He estimated total votes for Obama and Romney under a scenario where 2012 turnout rates for all racial groups matched those in 2004. Overall, 2012 voter turnout was roughly 58 percent, down from 62 percent in 2008 and 60 percent in 2004.

The analysis also used population projections to estimate the shares of eligible voters by race group through 2030. The numbers are supplemented with material from the Pew Research Center and George Mason University associate professor Michael McDonald, a leader in the field of voter turnout who separately reviewed aggregate turnout levels across states, as well as AP interviews with the Census Bureau and other experts. The bureau is scheduled to release data on voter turnout in May.

Overall, the findings represent a tipping point for blacks, who for much of America's history were disenfranchised and then effectively barred from voting until passage of the Voting Rights Act in 1965.

But the numbers also offer a cautionary note to both Democrats and Republicans after Obama won in November with a historically low percentage of white supporters. While Latinos are now the biggest driver of U.S. population growth, they still trail whites and blacks in turnout and electoral share, because many of the Hispanics in the country are children or noncitizens.

In recent weeks, Republican leaders have urged a "year-round effort" to engage black and other minority voters, describing a grim future if their party does not expand its core support beyond white males.

The 2012 data suggest Romney was a particularly weak GOP candidate, unable to motivate white voters let alone attract significant black or Latino support. Obama's personal appeal and the slowly improving economy helped overcome doubts and spur record levels of minority voters in a way that may not be easily replicated for Democrats soon.

Romney would have erased Obama's nearly 5 million-vote victory margin and narrowly won the popular vote if voters had turned out as they did in 2004, according to Frey's analysis. Then, white turnout was slightly higher and black voting lower.

More significantly, the battleground states of Ohio, Pennsylvania, Virginia, Florida and Colorado would have tipped in favor of Romney, handing him the presidency if the outcome of other states remained the same.

"The 2012 turnout is a milestone for blacks and a huge potential turning point," said Andra Gillespie, a political science professor at Emory University who has written extensively on black politicians. "What it suggests is that there is an 'Obama effect' where people were motivated to support Barack Obama. But it also means that black turnout may not always be higher, if future races aren't as salient."

Whit Ayres, a GOP consultant who is advising GOP Sen. Marco Rubio of Florida, a possible 2016 presidential contender, says the last election reaffirmed that the Republican Party needs "a new message, a new messenger and a new tone." Change within the party need not be "lock, stock and barrel," Ayres said, but policy shifts such as GOP support for broad immigration legislation will be important to woo minority voters over the longer term.

"It remains to be seen how successful Democrats are if you don't have Barack Obama at the top of the ticket," he said.

___

In Ohio, a battleground state where the share of eligible black voters is more than triple that of other minorities, 27-year-old Lauren Howie of Cleveland didn't start out thrilled with Obama in 2012. She felt he didn't deliver on promises to help students reduce college debt, promote women's rights and address climate change, she said. But she became determined to support Obama as she compared him with Romney.

"I got the feeling Mitt Romney couldn't care less about me and my fellow African-Americans," said Howie, an administrative assistant at Case Western Reserve University's medical school who is paying off college debt.

Howie said she saw some Romney comments as insensitive to the needs of the poor. "A white Mormon swimming in money with offshore accounts buying up companies and laying off their employees just doesn't quite fit my idea of a president," she said. "Bottom line, Romney was not someone I was willing to trust with my future."

The numbers show how population growth will translate into changes in who votes over the coming decade:

?The gap between non-Hispanic white and non-Hispanic black turnout in 2008 was the smallest on record, with voter turnout at 66.1 percent and 65.2 percent, respectively; turnout for Latinos and non-Hispanic Asians trailed at 50 percent and 47 percent. Rough calculations suggest that in 2012, 2 million to 5 million fewer whites voted compared with 2008, even though the pool of eligible white voters had increased.

?Unlike other minority groups, the rise in voting for the slow-growing black population is due to higher turnout. While blacks make up 12 percent of the share of eligible voters, they represented 13 percent of total 2012 votes cast, according to exit polling. That was a repeat of 2008, when blacks "outperformed" their eligible voter share for the first time on record.

?White voters also outperformed their eligible vote share, but not at the levels seen in years past. In 2012, whites represented 72 percent of total votes cast, compared to their 71.1 percent eligible vote share. As recently as 2004, whites typically outperformed their eligible vote share by at least 2 percentage points. McDonald notes that in 2012, states with significant black populations did not experience as much of a turnout decline as other states. That would indicate a lower turnout for whites last November since overall voter turnout declined.

?Latinos now make up 17 percent of the population but 11 percent of eligible voters, due to a younger median age and lower rates of citizenship and voter registration. Because of lower turnout, they represented just 10 percent of total 2012 votes cast. Despite their fast growth, Latinos aren't projected to surpass the share of eligible black voters until 2024, when each group will be roughly 13 percent. By then, 1 in 3 eligible voters will be nonwhite.

?In 2026, the total Latino share of voters could jump to as high as 16 percent, if nearly 11 million immigrants here illegally become eligible for U.S. citizenship. Under a proposed bill in the Senate, those immigrants would have a 13-year path to citizenship. The share of eligible white voters could shrink to less than 64 percent in that scenario. An estimated 80 percent of immigrants here illegally, or 8.8 million, are Latino, although not all will meet the additional requirements to become citizens.

"The 2008 election was the first year when the minority vote was important to electing a U.S. president. By 2024, their vote will be essential to victory," Frey said. "Democrats will be looking at a landslide going into 2028 if the new Hispanic voters continue to favor Democrats."

___

Even with demographics seeming to favor Democrats in the long term, it's unclear whether Obama's coalition will hold if blacks or younger voters become less motivated to vote or decide to switch parties.

Minority turnout tends to drop in midterm congressional elections, contributing to larger GOP victories as happened in 2010, when House control flipped to Republicans.

The economy and policy matter. Exit polling shows that even with Obama's re-election, voter support for a government that does more to solve problems declined from 51 percent in 2008 to 43 percent last year, bolstering the view among Republicans that their core principles of reducing government are sound.

The party's "Growth and Opportunity Project" report released last month by national leaders suggests that Latinos and Asians could become more receptive to GOP policies once comprehensive immigration legislation is passed.

Whether the economy continues its slow recovery also will shape voter opinion, including among blacks, who have the highest rate of unemployment.

Since the election, optimism among nonwhites about the direction of the country and the economy has waned, although support for Obama has held steady. In an October AP-GfK poll, 63 percent of nonwhites said the nation was heading in the right direction; that's dropped to 52 percent in a new AP-GfK poll. Among non-Hispanic whites, however, the numbers are about the same as in October, at 28 percent.

Democrats in Congress merit far lower approval ratings among nonwhites than does the president, with 49 percent approving of congressional Democrats and 74 percent approving of Obama.

William Galston, a former policy adviser to President Bill Clinton, says that in previous elections where an enduring majority of voters came to support one party, the president winning re-election ? William McKinley in 1900, Franklin D. Roosevelt in 1936 and Ronald Reagan in 1984 ? attracted a larger turnout over his original election and also received a higher vote total and a higher share of the popular vote. None of those occurred for Obama in 2012.

Only once in the last 60 years has a political party been successful in holding the presidency more than eight years ? Republicans from 1980-1992.

"This doesn't prove that Obama's presidency won't turn out to be the harbinger of a new political order," Galston says. "But it does warrant some analytical caution."

Early polling suggests that Democrat Hillary Rodham Clinton could come close in 2016 to generating the level of support among nonwhites as Obama did in November, when he won 80 percent of their vote. In a Fox News poll in February, 75 percent of nonwhites said they thought Clinton would make a good president, outpacing the 58 percent who said that about Vice President Joe Biden.

Benjamin Todd Jealous, president of the NAACP, predicts closely fought elections in the near term and worries that GOP-controlled state legislatures will step up efforts to pass voter ID and other restrictions to deter blacks and other minorities from voting. In 2012, courts blocked or delayed several of those voter ID laws and African-Americans were able to turn out in large numbers only after a very determined get-out-the-vote effort by the Obama campaign and black groups, he said.

Jealous says the 2014 midterm election will be the real bellwether for black turnout. "Black turnout set records this year despite record attempts to suppress the black vote," he said.

___

AP Director of Polling Jennifer Agiesta and News Survey Specialist Dennis Junius contributed to this report.

EDITOR'S NOTE _ "America at the Tipping Point: The Changing Face of a Nation" is an occasional series examining the cultural mosaic of the U.S. and its historic shift to a majority-minority nation.

Source: http://news.yahoo.com/first-black-voter-turnout-rate-passes-whites-115957314.html

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Iran's ex-president softens stance toward Israel

TEHRAN, Iran (AP) ? Iran's influential former president has expressed a softer stance toward the country's archenemy Israel in sharp contrast to President Mahmoud Ahmadinejad' typical anti-Israel remarks.

Several Iranian newspapers, including the pro-reform Shargh daily, on Monday quoted Akbar Hashemi Rafsanjani as saying: "We are not at war with Israel."

The remark is seen as part of growing calls by high-profile Iranian politicians, including potential presidential candidates, to repair Iran's image abroad. Ahmadinejad's comment in 2005 that Israel should be destroyed prompted an international outcry.

Last week, Mohammad Bagher Ghalibaf ? Tehran mayor who is considered a potential candidate in the June presidential election ? said the president's anti-Jewish remarks have damaged Iran.

Rafsanjani has not said whether he plans to run in the election.

Source: http://news.yahoo.com/irans-ex-president-softens-stance-toward-israel-072552780.html

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'90210's' Ziering welcomes second daughter

Getty Images file

Ian Ziering and Erin Ludwig.

By Erin O'Sullivan, Access Hollywood

It?s another girl for Ian Ziering!?The former ?90210? star and his wife, Erin, welcomed their second daughter on Thursday, according to People.

VIEW THE PHOTOS: MTV Movie Awards 2013: Red carpet styles!

The baby girl, named Penna Mae Ziering, arrived at 9:21 AM and weighed in at 6 lbs., 9 oz., according to the mag.

VIEW THE PHOTOS: "One Life To Live" & "All My Children": The New York City premiere!

Penna now shares the same birthday (April 25) as her big sister, 2-year-old Mia -- which Ian said was a surprise.

?We didn?t plan it!? he told the mag. ?Mia was born a week late and Penna was a week early.?

VIEW THE PHOTOS: "American Idol" season 12 -- countdown to the finale

The 49-year-old actor said Mia was thrilled over Penna?s arrival.

?She couldn?t wait to meet her,? he said. ?When she saw Penna she said, ?Baby sister!??

VIEW THE PHOTOS: "Arrested Development": Character posters & scenes from season 4

Ian and Erin began dating in 2009 and announced their engagement in February 2010.

They tied the knot on May 28, 2010 in Newport Beach, Calif.

Related content:

Source: http://todayentertainment.today.com/_news/2013/04/29/17968237-90210s-ian-ziering-welcomes-second-daughter-with-wife-erin?lite

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Steven Spielberg "Obama" Biopic - Business Insider

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Monday, April 29, 2013

Pat Healy submits Jim Miller at UFC 159, but Bruce Buffer almost announces wrong winner

Jim Miller is 5-foot-8, fights at 155 lbs., and has a bushy red beard. Pat Healy is 5-foot-9, fights at 155 lbs., and sported a trimmed red beard at UFC 159. Can you blame UFC announcer Bruce Buffer for mixing them up?

Healy, who returned to the UFC after spending much of his career in Strikeforce, put Miller to sleep with a rear naked choke in the third round of their thrilling bout. As the two stood on either side of referee Herb Dean to have the fight result announced, Buffer announced the winner by submission was Jim Mill-Pat Healy!

Healy smiled and corrected Buffer, who rarely makes such errors. It was a lighthearted moment that Healy laughed about after a thrilling bout.

Miller started out landing leg kicks and used ground and pound to beat up Healy in the first round. Near the end of the round, Healy was saved by the bell as Miller's ground and pound was close to ending the bout before the horn sounded.

[Also: Two bizarre endings mar UFC 159 prelims]

It was in the third that Healy turned the bout around. Healy weakened Miller with striking, then took him down and took his back. He sunk in the rear naked choke, and Miller's arms went limp. The fight was stopped at 4:02 in the third because Miller was out.

Miller wanted to use the bout to convince UFC president Dana White that he was ready for a title shot. Instead, it was Healy who stood out. In his post-fight interview with UFC commentator, he warned other UFC lightweights to watch out because he was "putting them on blast."

Other popular content on Yahoo! Sports:
? New Cardinals DB Tyrann Mathieu continues to raise red flags
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? Owner Jeffrey Loria further alienates Marlins, fans with lineup mandate
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Source: http://sports.yahoo.com/blogs/mma-cagewriter/pat-healy-submits-jim-miller-ufc-159-bruce-030349579.html

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Literary Pets: The Cats, Dogs, and Birds Famous Authors Loved ...

by Maria Popova

Twain and Bambino, Browning and Flush, Dickens and Grip, Hemingway and Uncle Willie, and more.

The wonderful recent Lost Cat memoir, one of my favorite books of the past few years, reminded me of how central, yet often unsuspected, a role pets have played in famous authors? lives throughout literary history.

Cats have inspired Joyce?s children?s books, T. S. Eliot?s poetry, Gay Talese?s portrait of New York, and various literary satire, while dogs have fueled centuries of literature, philosophy and psychology, interactive maps, and some of the New Yorker?s finest literature and art. Gathered here are some of literary history?s most moving accounts of famous writers? love for their pets, culled from a wealth of letters, journals, and biographies.

Bambino, photographed by Mark Twain's daughter, Jean Clemens (Image: Mark Twain Papers, University of California, Berkeley)

In between dispensing advice to little girls and epistolary snark to audacious grown-ups, Mark Twain grew deeply fond of the cat he had gotten for his daughter Clara during her extended illness. Writing in My Father, Mark Twain, Clara remembers:

In the early autumn Father rented a house on Fifth Avenue, corner of Ninth Street, number 21, where he, Jean, the faithful Katie, and the secretary settled down for the winter. I was taken to a sanatorium for a year. During the first months of my cure I was completely cut off from friends and family, with no one to speak to but the doctor and nurse. I must modify this statement, however, for I had smuggled a black kitten into my bedroom, although it was against the rules of the sanatorium to have any animals in the place. I called the cat Bambino and it was permitted to remain with me until the unfortunate day when it entered one of the patient?s rooms who hated cats. Bambino came near giving the good lady a cataleptic fit, so I was invited to dispose of my pet after that. I made a present of it to Father, knowing he would love it, and he did. A little later I was allowed to receive a limited number of letters, and Father wrote that Bambino was homesick for me and refused all meat and milk, but contradicted his statement a couple of days later saying: ?It has been discovered that the reason your cat declines milk and meat and lets on to live by miraculous intervention is, that he catches mice privately.?

One day, however, Bambino disappeared, and Twain took out an ad in the New York American, offering $5 for Bambino?s return and the following description:

Large and intensely black; thick, velvety fur; has a faint fringe of white hair across his chest; not easy to find in ordinary light.

Katy Leary, Twain?s faithful servant, recalls the incident in A Lifetime with Mark Twain:

One night he got kind of gay, when he heard some cats calling from the back fence, so he found a window open and he stole out. We looked high and low but couldn?t find him. Mr. Clemens felt so bad that he advertised in all the papers for him. He offered a reward for anybody that would bring the cat back. My goodness! the people that came bringing cats to that house! A perfect stream! They all wanted to see Mr. Clemens, of course.

Two or three nights after, Katherine heard a cat meowing across the street in General Sickles? back yard, and there was Bambino ? large as life! So she brought him right home. Mr. Clemens was delighted and then he advertised that his cat was found! But the people kept coming just the same with all kinds of cats for him ? anything to get a glimpse of Mr. Clemens!

Robert Pole and Tavi

Robert Pole, Ana?s Nin?s ?West Coast Husband,? was inseparable from his beloved spaniel named Tavi. A series of letters between the two, found in A Cafe in Space: The Anais Nin Literary Journal, Volume 5, embodies the tender soul-merging that happens when a significant other?s pet comes to move our own hearts with equal might. In early May of 1960, Pole writes:

My Love:

Quel jours! After wrote you from beach took Tavi to McWherter?s today (Monday after school) hoping he could help but fearing he?d want to put him to sleep. He?s having same thing with his mother so was very sympathetic ? ?Tiger? he called, but Tavi so limp and listless and not like a tiger at all ? but Mac gave him another kind of injection (to ?feed? the brain) and said lots of cockers have lived through strokes!! Said I could give him a little water after ? thank god as the ice bit was really getting me down ? also he can have a little ice cream to keep up his strength ? so I tore down to get some only to find he didn?t like it ? but he does seem little better today and is functioning normally (I take him out and hold him up to wee wee). School is not difficult ? I?m just as glad to have him in the car where he can?t hurt himself.

A few days later, Nin responds:

Darling chiquito:

Your letter about Tavi upset me so much I was sad all day. Just before I left I whispered in his ear that he should wait for me and keep well. I had an intuition, and I wrote you about it ? I was at Grazilla?s and seeing her dog I worried about Tavi ? I know what he means to us, yet darling, old age is so cruel it is better to not be alive ? and the Tavi we knew lately was not the real Tavi. He has had much love and care ? more than any dog I know. You know, he often wobbled to one side ? he must have had a slight stroke before ? I hate to think of Tavi being ill when I am not there to console you, to greet you when you come home. I hope perhaps it was a false alarm ? and he may be all well now ? I thought of you all day. Got your letter in the morning.

[?]

Te quiero chiquito ? love to Tavi?tell him to wait for me.

Love,

A.

But Tavi makes a miraculous recovery and, a short time later, Pole writes:

Tavi has not been swallowed by lion ? but is his old impossible self ? he now distains [sic] canned food ? so I cook pork liver for him ? and every day is a holiday ? for senior dogs.

Later in May:

Tavi has recovered completely ? in fact he has more energy saved up just to plague me with ? goes sideways and falls down occasionally but then as you say has been doing that for some time ? probably had his first stroke long ago.

By early June:

Tavi brimming with health ? he?ll outlive all of us ? no problem in his waiting ? but he does miss you?

The Faithful Friend: Elizabeth Barrett Browning and her cocker spaniel Flush (Artwork: ames E McConnell)

Elizabeth Barrett Browning was deeply attached to her cocker spaniel, Flush, a gift from her friend Mary Mitford. In 1826, Browning?s first collection of poems, which revealed her passion for Greek politics, caught the attention of a man named Hugh Stuart Boyd, a blind scholar of the Greek language. The two became correspondents and lifelong friends. Nearly two decades later, in March of 1842, Browning wrote in a letter to Boyd, found in The Unpublished Letters of Elizabeth Barrett Browning to Hugh Stuart Boyd:

It was very kind in you to pat Flush?s head in defiance of danger and from pure regard for me. I kissed his head where you had patted it; which association of approximations I consider as an imitation of shaking hands with you and as the next best thing to it. You understand ? don?t you? ? that Flush is my constant companion, my friend, my amusement, lying with his head on one page of my folios while I read the other. (Not your folios ? I respect your books, be sure.) Oh, I dare say, if the truth were known. Flush understands Greek excellently well.

In 1850, having just given birth to her only son at the age of 43, after four miscarriages, Browning writes in a letter to her friend Mr. Westwood:

You can?t think what a good, sweet, curious, imagining child he is. Half the day I do nothing but admire him ? there?s the truth. He doesn?t talk yet much, but he gesticulates with extraordinary force of symbol, and makes surprising revelations to us every half-hour or so. Meanwhile Flush loses nothing I assure you. On the contrary, he is hugged and kissed (rather too hard sometimes), and never is permitted to be found fault with by anybody under the new regime. If Flush is scolded, Baby cries as matter of course, and he would do admirably for a ?whipping-boy? if that excellent institution were to be revived by Young England and the Tractarians for the benefit of our deteriorated generations.

'Grip, The Late Mr. Charles Dickens's Raven' 1870 print (Image: Free Library of Philadelphia)

Charles Dickens had a beloved pet raven named Grip, who made frequent cameos in the writer?s fiction. In 1841, a few months after swallowing a paint chip, Grip perished. In a letter to his friend Daniel Maclise, found in The Selected Letters of Charles Dickens, Dickens pens a tongue-in-cheek sketch of Raven?s final moments:

Devonshire Terrace
Friday Evening
March The Twelfth 1841

My Dear Maclise

You will be greatly shocked and grieved to hear that the Raven is no more. He expired to-day at a few minutes after twelve o?clock, at noon. He had been ailing for a few days, but we anticipated no serious result, conjecturing that a portion of the white paint he swallowed last summer might be lingering about his vitals. Yesterday afternoon he was taken so much worse that I sent an express for the medical gentleman, who promptly attended and administered a powerful dose of castor oil. Under the influence of this medicine he recovered so far as to be able, at eight o?clock, P.M., to bite Topping [the coachman]. His night was peaceful. This morning, at daybreak, he appeared better, and partook plentifully of some warm gruel, the flavor of which he appeared to relish. Toward eleven o?clock he was so much worse that it was found necessary to muffle the stable knocker. At half-past, or thereabouts, he was heard talking to himself about the horse and Topping?s family, and to add some incoherent expressions which are supposed to have been either a foreboding of his approaching dissolution or some wishes relative to the disposal of his little property, consisting chiefly of half-pence which he has buried in different parts of the garden. On the clock striking twelve he appeared slightly agitated, but he soon recovered, walked twice or thrice along the coach-house, stopped to bark, staggered, exclaimed Halloa old girl! (his favorite expression) and died. He behaved throughout with decent fortitude, equanimity and self-possession. I deeply regret that, being ignorance of his last instructions.? The children seem rather glad of it. He bit their ankles but that was play?

After Grip died, Dickens had him taxidermied. Literary historians believe the bird inspired Edgar Alan Poe?s poem ?The Raven,? written shortly after Poe reviewed Dickens?s Bamaby Rudge, which features a talkative raven. Grip now lives in the Rare Books Department of the Free Library of Philadelphia.

E. B. White sitting on the beach with his dog Minnie (Image: Wikimedia Commons)

In the Spring of 1951, E. B. White was accused by the New York chapter of the ASPCA for not paying dog tax on his beloved canine companion, Minnie. True to his eloquent wit, he responded with this letter of uncommon mischievous charm, found in the anthology Letters of a Nation:

12 April 1951

The American Society for the Prevention of Cruelty to Animals
York Avenue and East 92nd Street
New York, 28, NY

Dear Sirs:

I have your letter, undated, saying that I am harboring an unlicensed dog in violation of the law. If by ?harboring? you mean getting up two or three times every night to pull Minnie?s blanket up over her, I am harboring a dog all right. The blanket keeps slipping off. I suppose you are wondering by now why I don?t get her a sweater instead. That?s a joke on you. She has a knitted sweater, but she doesn?t like to wear it for sleeping; her legs are so short they work out of a sweater and her toenails get caught in the mesh, and this disturbs her rest. If Minnie doesn?t get her rest, she feels it right away. I do myself, and of course with this night duty of mine, the way the blanket slips and all, I haven?t had any real rest in years. Minnie is twelve.

In spite of what your inspector reported, she has a license. She is licensed in the State of Maine as an unspayed bitch, or what is more commonly called an ?unspaded? bitch. She wears her metal license tag but I must say I don?t particularly care for it, as it is in the shape of a hydrant, which seems to me a feeble gag, besides being pointless in the case of a female. It is hard to believe that any state in the Union would circulate a gag like that and make people pay money for it, but Maine is always thinking of something. Maine puts up roadside crosses along the highways to mark the spots where people have lost their lives in motor accidents, so the highways are beginning to take on the appearance of a cemetery, and motoring in Maine has become a solemn experience, when one thinks mostly about death. I was driving along a road near Kittery the other day thinking about death and all of a sudden I heard the spring peepers. That changed me right away and I suddenly thought about life. It was the nicest feeling.

You asked about Minnie?s name, sex, breed, and phone number. She doesn?t answer the phone. She is a dachshund and can?t reach it, but she wouldn?t answer it even if she could, as she has no interest in outside calls. I did have a dachshund once, a male, who was interested in the telephone, and who got a great many calls, but Fred was an exceptional dog (his name was Fred) and I can?t think of anything offhand that he wasn?t interested in. The telephone was only one of a thousand things. He loved life ? that is, he loved life if by ?life? you mean ?trouble,? and of course the phone is almost synonymous with trouble. Minnie loves life, too, but her idea of life is a warm bed, preferably with an electric pad, and a friend in bed with her, and plenty of shut-eye, night and days. She?s almost twelve. I guess I?ve already mentioned that. I got her from Dr. Clarence Little in 1939. He was using dachshunds in his cancer-research experiments (that was before Winchell was running the thing) and he had a couple of extra puppies, so I wheedled Minnie out of him. She later had puppies by her own father, at Dr. Little?s request. What do you think about that for a scandal? I know what Fred thought about it. He was some put out.

Sincerely yours,

E. B. White

Montaigne and his cat

In one of his essays, admonishing against presumption, ?our natural and original disease,? Michel de Montaigne pondered the presumed indebtedness in the dynamic between him and his cat:

When I play with my cat who knows whether I do not make her more sport than she makes me? We mutually divert one another with our play. If I have my hour to begin or to refus, she also has hers.

Raymond Chandler and Taki (Image: Venture Galleries)

The direction of ownership, in fact, is often inverted between cats and their owners. Take, for instance, Raymond Chandler and his beloved, temperamental cat Taki. In a 1948 letter to his friend James Sandoe, found in Selected Letters of Raymond Chandler, Chandler lovingly grumbles:

Our cat is growing positively tyrannical. If she finds herself alone anywhere she emits blood curdling yells until somebody comes running. She sleeps on a table in the service porch and now demands to be lifted up and down from it. She gets warm milk about eight o?clock at night and starts yelling for it about 7.30. When she gets it she drinks a little, goes off and sits under a chair, then comes and yells all over again for someone to stand beside her while has another go at the milk. When we have company she looks them over and decides almost instantly if she likes them. If she does she strolls over the plops down on the floor far enough away to make it a chore to pet her. If she doesn?t like them, she sits in the middle of the living room, casts a contemptuous glance around, and proceeds to wash her backside.

Gertrude Stein and Alice B. Toklas in wallpapered room, 1938; photograph by Sir Cecil Beaton (Image: Cecil Beaton Archives, Sotheby's, London)

Ever since reading Henry James?s The Princess Casamassima, Alice B. Toklas, the love of Gertrude Stein?s life, had always wanted a white poodle. So the couple got one and named him Basket. Basket was succeeded by Basket I and Basket II. The dogs were photographed by Man Ray and Cecil Beaton. In The Autobiography of Alice B. Toklas, Stein?s famously faux-titled biography of Toklas and their life together, Stein recounts the story of the first Basket:

We now had our country house, the one we had only seen across the valley and just before leaving we found the white poodle, Basket. He was a little puppy in a little neighborhood dog-show and he had blue eyes, a pink nose and white hair and he jumped up into Gertrude Stein?s arms. A new puppy and a new ford and we went off to our new house and we were thoroughly pleased with all three. Basket although now he is a large unwieldy poodle, still will get up on Gertrude Stein?s lap and stay there. She says that listening to the rhythm of his water-drinking made her recognize the difference between sentences and paragraphs, that paragraphs are emotional and that sentences are not.

Bernard Fay came and stayed with us that summer. Gertrude Stein and he talked out in the garden about everything, about life, and America, and themselves and friendship. They then cemented the friendship that is one of the four permanent friendships of Gertrude Stein?s life. He even tolerated Basket for Gertrude Stein?s sake. Lately Picabia has given us a tiny mexican dog, we call Byron. Bernard Fay likes Byron for Byron?s own sake. Gertrude Stein teases him and says naturally he likes Byron best because Byron is american while just as naturally she likes Basket best because Basket is a frenchman.

It was part of Stein and Toklas?s daily routine to brush Basket?s teeth each morning with his own toothbrush.

Hemingway and cat(Image: JFK Library)

Ernest Hemingway, despite his manly bravado, had a soft spot for cats. By 1945, he had amassed 23 of them. His niece writes in the foreword to Hemingway?s Cats: An Illustrated Biography that the author and his fourth wife, Mary, called the cats ?purr factories? and ?love sponges. On February 22, 1953, one of Hemingway?s cats, Uncle Willie, was hit by a car. Following the accident, Hemingway sent his close friend Gianfranco Ivancich the following distraught and stirring letter, originally featured here last year:

Dear Gianfranco:

Just after I finished writing you and was putting the letter in the envelope Mary came down from the Torre and said, ?Something terrible has happened to Willie.? I went out and found Willie with both his right legs broken: one at the hip, the other below the knee. A car must have run over him or somebody hit him with a club. He had come all the way home on the two feet of one side. It was a multiple compound fracture with much dirt in the wound and fragments protruding. But he purred and seemed sure that I could fix it.

I had Ren? get a bowl of milk for him and Ren? held him and caressed him and Willie was drinking the milk while I shot him through the head. I don?t think he could have suffered and the nerves had been crushed so his legs had not begun to really hurt. Monstruo wished to shoot him for me, but I could not delegate the responsibility or leave a chance of Will knowing anybody was killing him?

Have had to shoot people but never anyone I knew and loved for eleven years. Nor anyone that purred with two broken legs.

William S. Burroughs and his cat Ginger in the backyard of his home in Lawrence, Kansas

William S. Burroughs was a tremendous cat-lover? so much so that he cracked his coarse and often icy literary persona to reveal a gentler, warmer side in The Cat Inside. He adored his ?psychic companions,? Fletch, Ruski, Spooner, and Calico. Writing in his journal in June of 1997, he captures the near-telepathic minimalism to which communication between pets and their pet-parents is perfected:

Ginger touches me with her old paw when she wants something. She just touched me, and I let her out.

In the final entry of his journal, the very last words he ever penned, Burroughs bequeaths:

Thinking is not enough. Nothing is. There is no final enough of wisdom, experience ? any fucking thing. Only thing can resolve conflict is love, like I felt for Fletch and Ruski, Spooner, and Calico. Pure love.

Love? What is It?
Most natural painkiller what there is.
LOVE.

Pair with Lost Cat: A True Story of Love, Desperation, and GPS Technology and the indispensable The Big New Yorker Book of Dogs.

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Source: http://www.brainpickings.org/index.php/2013/04/29/literary-pets/

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Gizmodo's Transformers Trip:How They're Made,Where They Come From

Recently, Gizmodo had a chance to go out to the Transformers HQ at Hasbro's home office outside of Providence, Rhode Island. We got to see how the classic toys are designed from the ground up, as well as the workshop where early prototypes for all of Hasbro's toys are put together. It was a pretty great time.

Autobots Assembled: How Transformers Come to Life

Some of the lead designers of the newest Transformers line took us through how they dream up, sketch out, and engineer the designs and transformations of your favorite Transformers characters.

Where the Toys Come From: Inside Hasbro?s Model Workshop

We took a tour around the Hasbro prototype workshop and saw how the earliest models of toys are put together?sometimes grown?right in the Hasbro's workshop. We saw 3D printers, master model makers at work, and the man who hand-paints every single Transformers prototype.

Michael Bay Is Why Transformers Got So Complicated

Transformers are HARD to put together. Some of the head designers explained how it got to be so bad, and why things are going to get better some time soon.

Here's a Skinless, Laughing Elmo to Terrify You Forever

We also saw this. It was horrifying.

Source: http://gizmodo.com/gizmodos-transformers-trip-how-theyre-made-and-where-484520999

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California police search for suspect in fatal stabbing of girl

(Reuters) - A manhunt was under way on Sunday in a northern California suburb for a suspect who authorities say stabbed a 9-year-old girl to death in a suburban home and fled, officials said.

Residents of Valley Springs, California, 60 miles southeast of Sacramento, were being warned on Sunday morning to remain inside their homes with their doors locked as investigators fanned out across the region, hunting for the suspected attacker.

Authorities said the victim's 12-year-old brother encountered an intruder in his home on Friday afternoon and the suspect fled, according to KCRA, a local television news station.

The boy went to check on his sister and found her stabbed. She was pronounced dead at a nearby hospital, KCRA reported.

The Calaveras County Sheriff's Department said in statement released on Sunday morning that the suspect may be armed and dangerous.

The department said multiple law enforcement agencies are on the lookout for a white or Hispanic man, about 6-feet tall and described as "muscular," with longish gray hair. They said he was wearing a long-sleeved black shirt and blue pants.

The victim's identity has not been released.

(Reporting by Chris Francescani; Editing by Barbara Goldberg and Jackie Frank)

Source: http://news.yahoo.com/california-police-search-suspect-fatal-stabbing-girl-161331492.html

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iMore show 347: Freemium frenzy

Georgia from ZEN & TECH joins Rene to talk about the true cost of freemium iPhone and iPad games. Why did freemium games come into being, how did they grow to dominate the charts, what causes us to keep feeding them, and when do they cross the line? Also: A surprise visit from Kevin Michaluk of CrackBerry!

Guests

Hosts

Credits

You can reach all of us on Twitter @iMore, or you can email us at podcast@imore.com or just leave us a comment below.

For all our podcasts -- audio and video -- including the iMore show, ZEN and TECH, Iterate, Debug, Ad hoc, and more, see MobileNations.com/shows

iMore show 340: Nerd Talking

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/hpzbJoo4eUA/story01.htm

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Obama to Nominate Foxx for Transportation Secretary (WSJ)

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Watch The Disrupt NY 2013 Hackathon Presentations Live

IMG_7217Disrupt NY 2013's Hackathon took place over roughly the last 24 hours, and now the teams are ready to present. Watch along as we live stream all 164 hacks built during the event, each of which gets just under a minute to demo what they've built on stage in order to try to convince the judges they're worthy of the sponsor prizes. 164 is a lot of hacks for just under a day, and in fact it's a record for any Disrupt Hackathon to date.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/LAaVZx7XLJc/

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Jews ease back into Tunisia for famed pilgrimage

Jewish pilgrims gather for a procession at the Ghriba synagogue, during the annual Jewish pilgrimage in the resort of Djerba, Tunisia, Friday April 26, 2013. They come to celebrate the annual rites at El-Ghriba, the oldest Jewish monument built in Africa more than 2,500 years ago. On April 11, 2002 a deadly attack on the synagogue killed 21 people, including 14 German tourists.(AP Photo/Hassene Dridi)

Jewish pilgrims gather for a procession at the Ghriba synagogue, during the annual Jewish pilgrimage in the resort of Djerba, Tunisia, Friday April 26, 2013. They come to celebrate the annual rites at El-Ghriba, the oldest Jewish monument built in Africa more than 2,500 years ago. On April 11, 2002 a deadly attack on the synagogue killed 21 people, including 14 German tourists.(AP Photo/Hassene Dridi)

Jewish pilgrims are gathered for a procession at the Ghriba synagogue, during the annual Jewish pilgrimage in the resort of Djerba, Tunisia, Friday April 26, 2013. They come to celebrate the annual rites at El-Ghriba, the oldest Jewish monument built in Africa more than 2,500 years ago. On April 11, 2002 a deadly attack on the synagogue killed 21 people, including 14 German tourists.(AP Photo/Hassene Dridi)

Jewish pilgrims are gathered for a procession at the Ghriba synagogue, during the annual Jewish pilgrimage in the resort of Djerba, Tunisia, Friday April 26, 2013. They come to celebrate the annual rites at El-Ghriba, the oldest Jewish monument built in Africa more than 2,500 years ago. On April 11, 2002 a deadly attack on the synagogue killed 21 people, including 14 German tourists.(AP Photo/Hassene Dridi)

Rabbi Mamou reads a holy book during the annual Jewish pilgrimage at the Ghriba synagogue in the resort of Djerba, Tunisia, Friday April 26, 2013. The pilgrimage to the synagogue commemorates the April 11, 2002 deadly attack on the synagogue that killed 21 people, including 14 German tourists. (AP Photo/Hassene Dridi)

Jewish pilgrims are gathered at the entrance of the Ghriba synagogue, during the annual Jewish pilgrimage in the resort of Djerba, Tunisia, Friday April 26, 2013. The pilgrimage to the synagogue commemorates the April 11, 2002 deadly attack on the synagogue that killed 21 people, including 14 German tourists.(AP Photo/Hassene Dridi)

(AP) ? Under a bright Mediterranean sun Saturday, Jews whose forebears once thronged Tunisia are trekking to a celebrated synagogue under the protection of police ? as organizers try to inject new momentum to an annual pilgrimage that's been depleted in recent years by fears of anti-Semitism.

Jewish leaders hope the three-day pilgrimage to the Ghriba synagogue, Africa's oldest, on the island of Djerba is regaining momentum after attendance plummeted in the wake of a 2002 al-Qaida bombing and lingering safety concerns following Tunisia's revolution two years ago.

The pilgrimage evokes a larger issue for Tunisia: How to convince Jews and other foreigners that stability has returned enough to merit a visit and help revive a weakened economy. The tourism trade accounts for about 400,000 jobs and 7 percent of economic output in Tunisia, an overwhelmingly Muslim country of nearly 11 million.

Despite the setbacks in recent years, Tunisia's Jews were sounding optimistic.

"This year will be better. The atmosphere is good, and the preparations have been made carefully," said Perez Trabelsi, the president of Ghriba's operating committee, and a Djerba native. "Attendance will go up from one year to the next, to return to its top level ? like before."

At its peak in 2000, about 8,000 Jews came ? many from Israel, Italy and France, where they or their forebears had moved over the years. Such crowds haven't returned since an al-Qaida-linked militant detonated a truck bomb at the synagogue in 2002, killing 21 people, mostly German tourists ? and badly jolting the now-tiny Jewish community.

The pilgrimage was called off in 2011 in the wake of Tunisia's revolution, when major street protests ousted longtime President Zine El Abidine Ben Ali, who fled to Saudi Arabia, and some ultraconservative Muslims called Salafis chanted anti-Semitic slogans at their rallies. Last year, the pilgrimage resumed on a tiny scale: Only 100 or so foreigners came. This year, community leaders hope 300 to 500 will have come.

Rene Trabelsi, a Paris-based tour operator, said the Tunisian government ? led by the moderate Islamic party Ennahda ? has "gone beyond our hopes" in providing security measures, police and troops for the pilgrimage.

After Saturday's Sabbath, the three-day pilgrimage was expected to culminate Sunday with the sale of necklaces, scarves and other craftwork to raise money for the synagogue. On Friday, as it got underway, families lit candles and the faithful marched through a white-washed archway lined with bunting and Tunisia's red crescent-and-star flag into the ornate, blue-and-white synagogue.

Jews have been living in Djerba since 500 B.C. The Jewish population has shrunk to 1,500, down from 100,000 in the 1960s. Most left following the 1967 war between Israel and Arab countries, and Socialist economic policies adopted by the government in the late 1960s also drove away many Jewish business owners.

Djerba, a dusty island of palm trees and olive groves, lures hundreds of thousands of tourists every year ? mainly Germans and French ? for its sandy beaches and rich history. The Ghriba synagogue, said to date to 586 B.C., itself once drew up to 2,000 visitors per day, Jewish leaders have said.

The site is rich with legend. The first Jews who arrived were said to have brought a stone from the ancient temple of Jerusalem that was destroyed by the Babylonians. The stone is kept in a grotto at the synagogue. Women and children descend into the grotto to place eggs scrawled with wishful messages on them.

The pilgrims, mostly Sephardic Jews with roots in Tunisia, come for the festivities starting 33 days after the Jewish holiday of Passover that include singing, dancing and drinking the traditional "boukha" brandy made from dates or figs.

At poolside at a posh Djerba hotel, some pilgrims reveled in the festivities ? and brushed off any concerns.

Emile Arki, a 63-year-old businessman who splits his time between Paris and California, said all too often "what's happening in Tunisia is exaggerated with an alarmist tone ... We were well greeted at the airport. The people are smiling. I don't see why anybody should be afraid."

The religious affairs minister sent an adviser to "congratulate our Jewish brothers during their festival," and the tourism minister was expected on Sunday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-27-Tunisia-Jewish%20Pilgrimage/id-bd947c280c1440e8a68860608f770972

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B787 1st test flight in Japan since battery fire

TOKYO (AP) ? Japan's All Nippon Airways has successfully conducted its first test flight of the Boeing 787 aircraft since battery problems grounded the planes earlier this year.

Ray Conner, president of Boeing's consumer airline division, and ANA President Shinichiro Ito were aboard the flight Sunday.

The aircraft safely completed a two-hour flight before returning to Tokyo's Haneda Airport.

Batteries aboard two 787s failed less than two weeks apart in January, causing a fire aboard one plane and smoke in another. The root cause of those problems is still unknown.

Boeing has since developed and tested a revamped version of the battery system, with changes designed to prevent and contain a fire.

Japan's transport ministry approved Boeing's modifications Friday following similar steps by the U.S. Federal Aviation Administration.

Source: http://news.yahoo.com/b787-1st-test-flight-japan-since-battery-fire-061821252.html

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Video: Conan O'Brian to host the White House Correspondents' Dinner (cbsnews)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/302024260?client_source=feed&format=rss

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